Aplastic Anemia Pathophysiology and Treatment Schrezenmeier Bacigalupo Hardback

Description: Aplastic Anemia Pathophysiology and Treatment Comprehensive and up-to-date clinical reference, with an emphasis on treatment. Hubert Schrezenmeier (Edited by), Andrea Bacigalupo (Edited by) 9780521641012, Cambridge University Press Hardback, published 11 November 1999 403 pages 25.5 x 19.3 x 2.5 cm, 1.105 kg 'Aplastic anemia (AA) is a rare, complex, and often fatal disease that with appropriate therpy today has a high cure rate. This book is an excellent review of this disease with special emphasis on the different therapeutic modalities. It is a must read for all fellows in hematology/oncology, as well as other physicians taking care of patients with AA or Fanconi's anemia. It is also an important resource of information and will serve as a reference manual well into the new century.' Brynjar Vidarsson, Oncology/Karger This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. As well as a detailed overview of the pathophysiology of the disease, the international team of authors cover all aspects of management, including the established approaches of bone marrow transplantation and immunosuppressive treatment, new approaches such as the use of hematopoietic growth factors and escalated immunosuppression, and controversial issues such as stem cell transplantation. Also included is an important international consensus document on treatment, and a final section concentrates on the inherited syndrome Fanconi's anemia. Detailed treatment guidelines are given, making this the definitive resource for hematologists and other clinicians involved in the management and supportive care of patients with aplastic anemia. Scientists interested in bone marrow failure will also find this an invaluable reference. Part I. Pathophysiology of Acquired Aplastic Anemia: 1. Stem cell defect in aplastic anemia J. C. W. Marsh and N. G. Testa 2. Cytokine abnormalities in aplastic anemia S. Kojima 3. Role of T-lymphocytes and apoptosis in pathophysiology of aplastic anemia S. Nakao 4. Role of apoptosis in pathophysiology of aplastic anemia F. M. Gibson, N. J. Philpott, J. C. W. Marsh and E. C. Gordon-Smith 5. Interrelation between aplastic anemia and paroxysmal nocturnal hemoglobinuria G. Socié, J.-Y. Mary, H. Schrezenmeier and E. Gluckman 6. Aplastic anemia and other clonal disorders A. Raghavachar Part II. Epidemiology and Clinical Features of Acquired Aplastic Anemia: 7. Epidemiology and etiology of aplastic anemia H. Heimpel 8. Clinical presentation, natural course and prognostic factors P. Marin-Fernandez Part III. Treatment of Acquired Aplastic Anemia: 9. Supportive treatment of patients with severe aplastic anemia P. Ljungman 10. Immunosuppressive treatment of aplastic anemia A. Bacigalupo, H. Schrezenmeier and A. Tichelli 11. Role of cytokines in the treatment of aplastic anemia H. Schrezenmeier 12. HLA-identical sibling bone marrow transplantation to treat severe aplastic anemia S. R. McCann, J. R. Passweg, R. Storb and H. J. Deeg 13. Alternative donor bone marrow transplantation for severe acquired aplastic anemia J. M. Hows, J. V. Stone and B. M. Camitta 14. Treatment of children with acquired aplastic anemia A. Locasciulli 15. Long-term follow up of patients with aplastic anemia A. Tichelli and G. Socié 16. Guidelines for treatment of aplastic anemia (international consensus document) Part IV. Fanconi's Anemia: 17. Clinical features and diagnosis of Fanconi's anemia B. P. Alter 18. Genetic basis of Fanconi's anemia M. Buchwald and M. Carreau 19. Treatment of Fanconi's anemia E. Gluckman, G. Socié and P. Guardiola 20. Genetic correction of Fanconi's anemia J. M. Liu. Subject Areas: Haematology [MJF]

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