Modelling Proteasome Dynamics in a Bayesian Framework by Sabine St?bler (English

Description: Modelling Proteasome Dynamics in a Bayesian Framework by Sabine StÜbler Estimated delivery 3-12 business days Format Paperback Condition Brand New Description Sabine StÜbler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. Publisher Description Sabine StÜbler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitors transport parameters for strong or isoform-specific inhibition. Author Biography Sabine StÜbler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model. Details ISBN 3658201665 ISBN-13 9783658201661 Title Modelling Proteasome Dynamics in a Bayesian Framework Author Sabine StÜbler Format Paperback Year 2017 Pages 96 Edition 1st Publisher Springer Fachmedien Wiesbaden GE_Item_ID:137942416; About Us Grand Eagle Retail is the ideal place for all your shopping needs! With fast shipping, low prices, friendly service and over 1,000,000 in stock items - you're bound to find what you want, at a price you'll love! Shipping & Delivery Times Shipping is FREE to any address in USA. Please view eBay estimated delivery times at the top of the listing. Deliveries are made by either USPS or Courier. We are unable to deliver faster than stated. International deliveries will take 1-6 weeks. NOTE: We are unable to offer combined shipping for multiple items purchased. This is because our items are shipped from different locations. Returns If you wish to return an item, please consult our Returns Policy as below: Please contact Customer Services and request "Return Authorisation" before you send your item back to us. Unauthorised returns will not be accepted. Returns must be postmarked within 4 business days of authorisation and must be in resellable condition. Returns are shipped at the customer's risk. We cannot take responsibility for items which are lost or damaged in transit. For purchases where a shipping charge was paid, there will be no refund of the original shipping charge. Additional Questions If you have any questions please feel free to Contact Us. Categories Baby Books Electronics Fashion Games Health & Beauty Home, Garden & Pets Movies Music Sports & Outdoors Toys

Price: 68.94 USD

Location: Fairfield, Ohio

End Time: 2024-12-22T09:43:14.000Z

Shipping Cost: 0 USD