Description: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens by Martin Lorenz Stein Martin Steins thesis describes a novel methodology for natural product discovery. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Martin Steins thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals. Back Cover Martin Steins thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals. Table of Contents Introduction.- Objective.- Materials and Methods.- Results.- Discussion. Feature Nominated as an Outstanding Ph.D. thesis by TU M Details ISBN3319079131 Author Martin Lorenz Stein Series Springer Theses ISBN-10 3319079131 ISBN-13 9783319079134 Format Hardcover Year 2014 Short Title NMR-BIOASSAY GUIDED ISOLATION Edition Description 2014 Language English Media Book Imprint Springer International Publishing AG Subtitle A Novel NMR-Tool for Natural Product Detection Place of Publication Cham Country of Publication Switzerland Illustrations 24 Illustrations, color; 4 Illustrations, black and white; XVI, 71 p. 28 illus., 24 illus. in color. Pages 71 DOI 10.1007/978-3-319-07914-1 Edition 2014th Publisher Springer International Publishing AG Publication Date 2014-07-17 Alternative 9783319383996 DEWEY 572 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:135464197;
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ISBN-13: 9783319079134
Book Title: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhib
Publisher: Springer International Publishing Ag
Publication Year: 2014
Subject: Chemistry
Item Height: 235 mm
Number of Pages: 71 Pages
Language: English
Publication Name: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens: A Novel NMR-Tool for Natural Product Detection
Type: Textbook
Author: Martin Lorenz Stein
Item Width: 155 mm
Format: Hardcover
