Resistance to Proteasome Inhibitors in Cancer

Description: Resistance to Proteasome Inhibitors in Cancer Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Molecular Mechanisms and Strategies to Overcome Resistance Author(s): Q. Ping Dou Format: Hardback Publisher: Springer International Publishing AG, Switzerland Imprint: Springer International Publishing AG ISBN-13: 9783319067513, 978-3319067513 Synopsis The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway ([url] ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.

Price: 105.15 GBP

Location: Aldershot

End Time: 2025-01-23T09:21:47.000Z

Shipping Cost: 41 GBP