Description: Resistance to Proteasome Inhibitors in Cancer : Molecular Mechanisms and Strategies to Overcome Resistance, Hardcover by Dou, Q. Ping (EDT), ISBN 3319067516, ISBN-13 9783319067513, Brand New, Free P&P in the UK
Th explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume.
This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies.
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Book Title: Resistance to Proteasome Inhibitors in Cancer : Molecular Mechani
Number of Pages: 390 Pages
Language: English
Publication Name: Resistance to Proteasome Inhibitors in Cancer: Molecular Mechanisms and Strategies to Overcome Resistance
Publisher: Springer International Publishing A&G
Publication Year: 2014
Subject: Medicine, Biology
Item Height: 235 mm
Item Weight: 8005 g
Type: Textbook
Author: Q. Ping Dou
Series: Resistance to Targeted Anti-Cancer Therapeutics
Item Width: 155 mm
Format: Hardcover
