Resistance to Proteasome Inhibitors in Cancer: Molecular Mechanisms and Strategi

Description: Resistance to Proteasome Inhibitors in Cancer by Q. Ping Dou Resistance to Proteasome Inhibitors in Cancer FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume.This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies. Back Cover The book explores cutting-edge strategies to overcome proteasome inhibitor resistance, including the second generation 20S proteasome inhibitors, novel combinational therapies, and new targets in the ubiquitin-proteasome pathway (e.g., ubiquitin E3 ligases, deubiquitinases, 19S proteasomal ATPases, histone deacetylases, oxidative stress and proteotoxic stress pathways and pharmacogenomic signature profiling) in resistant cancer cells. The mechanisms of action and resistance of proteasome inhibitors, such as bortezomib and carfilzomib in human cancers, including multiple myeloma, mantle cell lymphoma, acute leukemia, and solid tumors are explored in depth in this volume. This timely volume unveils the most current discoveries of the mechanisms behind proteasome inhibitor resistance, which will help illuminate the future of cancer therapies. Author Biography Q. Ping Dou, Ph.D. is Professor of Pathology, Cancer Biology and Pharmacology at Wayne State University School of Medicine. Dr. Dous laboratory is one of the first to report that proteasome inhibitors rapidly induce tumor cell apoptosis, selectively activate the cell death program in oncogene-transformed, but not normal or untransformed cells and are able to trigger apoptotic death in human cancer cells that are resistant to various anticancer agents. He also serves on multiple editorial boards, including The Open Leukemia Journal, Journal of Clinical Oncology, Frontiers of Bioscience, to name a few. Table of Contents Proteasome inhibitors and lessons learned from their mechanisms of action and resistance in human cancer.- Resistance to proteasome inhibitors in multiple myeloma.- Overcoming bortezomib resistance: a review on the second generation proteasome inhibitor carfilzomib in the treatment of multiple myeloma .- Proteasome inhibitors in the treatment of multiple myeloma and amyloidosis.- Profiling bortezomib resistance in multiple myeloma: implications in personalized pharmacotherapy.- Targeting mantle cell lymphoma with a strategy of combined proteasome and histone deacetylase inhibition.- Pre-clinical studies on the molecular basis of bortezomib resistance and modalities to overcome resistance in hematological malignancies.- Overcoming inherent resistance to proteasome inhibitors in head and neck cancer: Challenges and new approaches.- Targeting the proteasome pathway for the treatment of solid tumors.- Oxidative stress and the proteasome: mechanism and the therapeutic relevance.- Proteotoxic stress and proteasome inhibitor efficacy and resistance.- Proteasome inhibitors versus E3 ligase inhibitors for cancer therapy.- Novel ubiquitin E3 ligases as targets for cancer therapy: Focus on breast cancer associated gene 2 (BCA2).- The 26S proteasomal ATPases: structure, function, regulation and potential for cancer therapies.- Deubiquitinating enzymes as novel targets for cancer therapies Feature Reveals latest discoveries related to the molecular mechanisms of proteasome inhibitor resistance Discusses proteasome inhibitor resistance in multiple contexts, including multiple myeloma, leukemia, mantle cell lymphoma, melanoma and other cancers Explores multiple, cutting-edge strategies to overcome resistance Details ISBN3319067516 Year 2014 ISBN-10 3319067516 ISBN-13 9783319067513 Format Hardcover Pages 390 Short Title RESISTANCE TO PROTEASOME INHIB Edition Description 2014 Language English Media Book Imprint Springer International Publishing AG Subtitle Molecular Mechanisms and Strategies to Overcome Resistance Place of Publication Cham Country of Publication Switzerland Edited by Q. Ping Dou DOI 10.1007/978-3-319-06752-0 Author Q. Ping Dou Publisher Springer International Publishing AG Series Resistance to Targeted Anti-Cancer Therapeutics Publication Date 2014-09-26 Alternative 9783319377032 DEWEY 616.99407 Audience Professional & Vocational Illustrations 51 Illustrations, color; 4 Illustrations, black and white; XI, 390 p. 55 illus., 51 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96358240;

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