The Proteasome Ubiquitin Protein Degradation Pathway by Peter Zwickl (English) P

Description: The Proteasome Ubiquitin Protein Degradation Pathway by Peter Zwickl, Wolfgang Baumeister The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui tination machinery. The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance. Notes Springer Book Archives Back Cover This volume gives a complete overview of the structure and function of the proteasome, its regulators and inhibitors, and its cellular importance, in conjunction with the ubiquitin system, for the degradation of regulatory proteins and the generation of immunogenic peptides. The topics range from the molecular evolution of the proteasome and its associated activators, the proteasome in the immune response, to proteasome inhibitors. Table of Contents List of Contents.- Molecular Evolution of Proteasomes.- The 20S Proteasome.- Regulating the 26S Proteasome.- The 11S Regulators of 20S Proteasome Activity.- Immunological Functions of the Proteasome.- Natural Substrates of the Proteasome and Their Recognition by the Ubiquitin System.- The Intracellular Localization of the Proteasome.- Proteasome Inhibitors: Complex Tools for a Complex Enzyme. Promotional Springer Book Archives Long Description This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu Feature Includes supplementary material: sn.pub/extras Details ISBN3642639712 Language English ISBN-10 3642639712 ISBN-13 9783642639715 Media Book Format Paperback Series Number 268 Short Title PROTEASOME UBIQUITIN PROTEIN D Year 2011 Publication Date 2011-09-18 Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany Edited by Wolfgang Baumeister Pages 208 DOI 10.1007/978-3-642-59414-4 Author Wolfgang Baumeister Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Edition Description Softcover reprint of the original 1st ed. 2002 Series Current Topics in Microbiology and Immunology Alternative 9783540430964 DEWEY 570 Audience Professional & Vocational Illustrations X, 208 p. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96324846;

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